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Sharaf Eldin, N., Omar, S., Abd El-Mouaty, H., Heikal, L., Hemdan, M. (2022). POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY. ALEXMED ePosters, 4(3), 15-16. doi: 10.21608/alexpo.2022.152829.1443
Nadia Sharaf Eldin; Sahar Omar; Hala Abd El-Mouaty; Lamia Heikal; Maha Hammady Hemdan. "POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY". ALEXMED ePosters, 4, 3, 2022, 15-16. doi: 10.21608/alexpo.2022.152829.1443
Sharaf Eldin, N., Omar, S., Abd El-Mouaty, H., Heikal, L., Hemdan, M. (2022). 'POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY', ALEXMED ePosters, 4(3), pp. 15-16. doi: 10.21608/alexpo.2022.152829.1443
Sharaf Eldin, N., Omar, S., Abd El-Mouaty, H., Heikal, L., Hemdan, M. POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY. ALEXMED ePosters, 2022; 4(3): 15-16. doi: 10.21608/alexpo.2022.152829.1443

POSSIBLE PROTECTIVE ROLE OF RESVERATROL-LOADED LIPOSOMES IN A RAT MODEL OF DOXORUBICIN-INDUCED CARDIOTOXICITY

Article 3, Volume 4, Issue 3, September 2022, Page 15-16  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2022.152829.1443
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Authors
Nadia Sharaf Eldin1; Sahar Omar1; Hala Abd El-Mouaty1; Lamia Heikal2; Maha Hammady Hemdan email orcid 1
1Histology and Cell Biology, Faculty of Medicine, Alexandria University
2Pharmaceutics, Faculty of Pharmacy, Alexandria University.
Abstract
Introduction:
Doxorubicin is a highly effective and widely used chemotherapeutic agent in treating wide variety of tumors. Unfortunately, cardiotoxicity is its most serious side effect, which is directly linked to the oxidative stress caused by DOX. Resveratrol is a powerful antioxidant, but its low bioavailability limits its use. Multilamellar liposomes are lipid nanocarriers. They are recently used as a carrier to enhance the bioavailability of many drugs by increasing their plasma half-life.
Aim of the work:
The current study was designed to histologically assess the myocardial alterations following induction of cardiotoxicity in adult male albino rats by doxorubicin and to evaluate the possible protective efficacy of RSV-loaded multilamellar liposomes on DOX-induced cardiotoxicity.
Materials and methods:
The present study was conducted over 5 successive weeks on 30 adult male albino rats which were categorized into 2 equal groups. Group I which was subdivided randomly into 3 equal subgroups: subgroup IA received physiological saline twice/week by intraperitoneal (i.p) injection, subgroup IB received daily oral suspension of unloaded multilamellar liposomes and subgroup IC received daily oral suspension of RSV-loaded multilamellar liposomes. Group II which was also equally subdivided into 3 subgroups (IIA, IIB and IIC), all of which received i.p injection of add the dose DOX twice/week I.P. for 5 successive weeks. In addition, subgroups IIB and IIC received daily oral suspension of unloaded multilamellar liposomes, and RSV-loaded multilamellar liposomes respectively. At the end of the experiment, cardiac apices specimens of all rats were obtained, processed and examined by light and electron microscopes.
Keywords
Doxorubicin (DOX); Resveratrol (RSV); liposomes
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