1Clinical pathology department, Alexandria Faculty of Medecine
2department of internal medicine hematology unit
3Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Egypt
Abstract
Acute myeloid leukemia is a form of hematopoietic progenitor cell cancer that causes an increase in the number of immature myeloid cells in the bone marrow In Egypt, leukemia accounts for 10% of all cancers, with AMLaccounting for 16.9%.AML becomes increasingly frequent as people age. The typical age of onset is roughly seventy years. Men are more likely than women to have AML. In the last decade, evidence of links between a variety of long non coding RNAs (lncRNAs) and leukemia pathophysiology has increased. LncRNAsare transcripts that are longer than 200 nucleotides and do not code for proteins. They play a role in cellular processes including gene regulation, as well as the carcinogenesis, growth, and prognosis of various tumors.HOTAIR is one of lncRNAs that plays a key role in the development of cancers such as acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), and multiple myeloma. HOTAIR expression was found to be substantially higher in leukemic cell lines and primary AML blasts. Clinically, AML patients with a higher HOTAIR had a worse prognosis than those with a lower HOTAIR.Previous researches have investigated HOTAIR and c-kit receptor (CD117) expression independently and their effect on prognosis of AML patients.
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