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El-Taweel, G., El-Gendi, S., Darwish, A., Mohamed Elgamasi, Y. (2022). TWIST-1 EXPRESSION AND ITS ASSOCIATION WITH CANCER STEMNESS IN COLORECTAL CARCINOMA. ALEXMED ePosters, 4(2), 27-28. doi: 10.21608/alexpo.2022.143399.1418
Galila El-Taweel; Saba El-Gendi; Azza Darwish; Yasmin Hamdi Mohamed Elgamasi. "TWIST-1 EXPRESSION AND ITS ASSOCIATION WITH CANCER STEMNESS IN COLORECTAL CARCINOMA". ALEXMED ePosters, 4, 2, 2022, 27-28. doi: 10.21608/alexpo.2022.143399.1418
El-Taweel, G., El-Gendi, S., Darwish, A., Mohamed Elgamasi, Y. (2022). 'TWIST-1 EXPRESSION AND ITS ASSOCIATION WITH CANCER STEMNESS IN COLORECTAL CARCINOMA', ALEXMED ePosters, 4(2), pp. 27-28. doi: 10.21608/alexpo.2022.143399.1418
El-Taweel, G., El-Gendi, S., Darwish, A., Mohamed Elgamasi, Y. TWIST-1 EXPRESSION AND ITS ASSOCIATION WITH CANCER STEMNESS IN COLORECTAL CARCINOMA. ALEXMED ePosters, 2022; 4(2): 27-28. doi: 10.21608/alexpo.2022.143399.1418

TWIST-1 EXPRESSION AND ITS ASSOCIATION WITH CANCER STEMNESS IN COLORECTAL CARCINOMA

Article 3, Volume 4, Issue 2, June 2022, Page 27-28  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2022.143399.1418
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Authors
Galila El-Taweel1; Saba El-Gendi1; Azza Darwish2; Yasmin Hamdi Mohamed Elgamasi email 1
1Department of Pathology, Faculty of Medicine, Alexandria University
2Department of clinical oncology and nuclear medicine, Faculty of Medicine, Alexandria University
Abstract
Introduction

Colorectal cancer (CRC) is considered to be the third most common malignancy worldwide, It is the fourth cause of cancer related death. Epithelial mesenchymal transition (EMT) plays a pivotal role in tumor invasion and metastasis. Recent studies have linked Twist-1 expression with EMT in different cancer cells including CRC bonding its expression with a more aggressive tumor phenotype and a poorer clinical outcome. The EMT phenotype has been also implicated in the acquisition of cancer stem cell (CSC) like properties. CD44 is believed to represent one of the main colorectal cancer stem cell markers. It plays a role in tumorigensis through stimulating several signaling pathways that maintain stemness of malignant tumors. Thus, Twist-1 and CD44 represent potential prognostic markers.

Aim of the Work

The current work was carried out to study the immuno-histochemical (IHC) expression of both Twist-1 and CD44 in CRC and to correlate this expression with the different clinicopathologic parameters and patients’ outcome .
Keywords
TWIST-1; CD44; COLORECTAL CARCINOMA
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