OVERCOMING MULTIDRUG RESISTANCE OF TRIPLE NEGATIVE BREAST CANCER CELL LINE USING miRNA 374C-5PCHITOSAN NANOPARTICLE CONJUGATES

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Alexandria University

2 Department of Pathology, Faculty of Medicine, Alexandria University

Abstract

Breast cancer is considered the 2nd highest in incidence at 17.9% accounting for 38.8% of all the female cases of cancers recorded in Egypt and the 2ndleading cause of death at 10.8%.
Amongst the molecular subtypes of breast cancer, Triple negative breast cancer (TNBC) is marked as the most aggressive. It constitutes 15-20% of breast cancers. It is associated with earlier age of onset, aggressive clinical course, and dismal prognosis.
Although strategies targeting breast cancer have already been improved, systemic treatments to guard against metastasis are less effective. It is therefore essential to develop novel therapeutics for the control of breast cancer initiation and progression.
The emergence of non-coding RNAs (ncRNAs) as crucial regulators of gene expression has raised exciting possibilities towards them being explored as alternative therapeutics for the management of various pathological conditions including breast cancer.
To find a safe and efficient non-viral vector for miRNA delivery, we investigated the interaction between chitosans and miRNA374C-5P and the influence of the resulting CS–miRNA complexes on the uptake of miRNA into triple negative breast cancer lines (MDA-MB-231).

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