Karkour, T., Abdel fatah, E., Abd Aldayem, T., Kholeif, D., Elssaidi, M. (2022). CLUSTER OF DIFFERENTATION 4/CLUSTER OF DIFFERENTATION 8 RATIO OF T-LYMPHOCYTE SUBSETS IN EGYPTIAN PATIENTS WITH SEVERE PREECLAMPSIA. ALEXMED ePosters, 4(1), 20-21. doi: 10.21608/alexpo.2022.119906.1360
Tarek Karkour; Eman Aly Abdel fatah; Tamer Abd Aldayem; Dina Kholeif; Mohamad Mostafa Elssaidi. "CLUSTER OF DIFFERENTATION 4/CLUSTER OF DIFFERENTATION 8 RATIO OF T-LYMPHOCYTE SUBSETS IN EGYPTIAN PATIENTS WITH SEVERE PREECLAMPSIA". ALEXMED ePosters, 4, 1, 2022, 20-21. doi: 10.21608/alexpo.2022.119906.1360
Karkour, T., Abdel fatah, E., Abd Aldayem, T., Kholeif, D., Elssaidi, M. (2022). 'CLUSTER OF DIFFERENTATION 4/CLUSTER OF DIFFERENTATION 8 RATIO OF T-LYMPHOCYTE SUBSETS IN EGYPTIAN PATIENTS WITH SEVERE PREECLAMPSIA', ALEXMED ePosters, 4(1), pp. 20-21. doi: 10.21608/alexpo.2022.119906.1360
Karkour, T., Abdel fatah, E., Abd Aldayem, T., Kholeif, D., Elssaidi, M. CLUSTER OF DIFFERENTATION 4/CLUSTER OF DIFFERENTATION 8 RATIO OF T-LYMPHOCYTE SUBSETS IN EGYPTIAN PATIENTS WITH SEVERE PREECLAMPSIA. ALEXMED ePosters, 2022; 4(1): 20-21. doi: 10.21608/alexpo.2022.119906.1360
CLUSTER OF DIFFERENTATION 4/CLUSTER OF DIFFERENTATION 8 RATIO OF T-LYMPHOCYTE SUBSETS IN EGYPTIAN PATIENTS WITH SEVERE PREECLAMPSIA
2Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University
3Obstetric and Gynecology department, faculty of Medicine, Alexandria University, Alexandria
4Department of Microbiology and Immunology Faculty of Medicine
5Department of Obstetrics and gynecology Faculty of Medicine
Abstract
Preeclampsia known as a disease of vasospasm caused by extensive vascular endothelial dysfunction which occurs after 20 weeks gestation and can appear within 6 weeks after delivery. Hypertension and proteinuria are characteristics associated with presence or absence of edema. Preeclampsia is a condition that affects pregnant women by 5-14% of all pregnancies.The T- helper lymphocytes express the cluster differentiation 4 (CD4+) molecules whereas the cytotoxic T-cells express cluster differentiation 8 (CD8+) molecules. Both CD4+ cell and CD8+ cell count are used to assess the strength of an individual’s immune response. Other assays that can be used to evaluate of immune condition include CD4/CD8 ratio, CD4 as well as CD8 percentages.
AIM OF THE WORK:
The aim of this work is to estimate CD4 and CD8 levels in peripheral blood and to get CD4/CD8 ratio in preeclamptic Egyptian patients to evaluate the immunological role in preeclampsia.
PATIENTS:
This case control study was conducted on 50 pregnant women in third trimester admitted to El-Shatby Maternity University Hospital 25 cases with severe preeclampsia diagnosed by clinical findings, laboratory investigations and ultrasonography admitted at eclampsia unit and 25 normal pregnant females from obstetric clinic.
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