EFFECT OF ISOTRETINOIN TREATMENT ON P53 EXPRESSION IN THE PILOSEBACEOUS GLANDS IN PATIENTS WITH ACNE VULGARIS

Document Type : Preliminary preprint short reports of original research

Authors

1 Department of Dermatology,Faculty of Medicine- Alexandria University

2 Department of Dermatology, Faculty of Medicine- Alexandria University

3 Medical Biochemistry,Faculty of Medicine- Alexandria University

4 Department of Pathology, Faculty of Medicine- Alexandria University

Abstract

INTRODUCTION
Acne is one of the most common skin disorders treated by dermatologists and other health care providers. It is a chronic inflammatory skin condition.
Several drugs are used in the treatment of acne vulgaris, Isotretinoin (13-cis-retinoic acid) is the most effective drug used in the treatment of moderate to severe acne vulgaris.
Treatment with isotretinoin results in sebaceous glands shrinkage and reduced sebum production.
Many authors had suggested that the main role of systemic isotretinoin is sebocyte apoptosis in different ways. This apoptosis was hypothesized to be due to increased p53 expression.
AIM OF THE WORK
The aim of this work was to detect the effect of oral isotretinoin on the expression of p53 in tissues by immunohistochemistry, ELISA and PCR through taking skin biopsies before and after isotretinoin treatment in patients with acne vulgaris.
SUBJECTS AND METHODS
Subject:
This study was conducted on: Twenty five patients suffering from acne vulgaris. And fifteen acne-free subjects were representing controls.
The Exclusion criteria: History of intake of systemic retinoids in the last six months, Patients on antibiotic therapy in the last six months, Smoking., Female patients on anti-androgen therapy in the last six months.

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