ANGIOPOIETIN LIKE PROTEIN 8 AND HIGH SENSITIVE C REACTIVE PROTEIN AS EARLY PREDICTORS OF GESTATIONAL DIABETES

Khamis, Mohamed Yousri; Swelem, Manal Shafik; Nabil, Yasmin Mahmoud; Moawad, Mohamed Ramadan

doi:10.21608/alexpo.2021.104803.1308

ANGIOPOIETIN LIKE PROTEIN 8 AND HIGH SENSITIVE C REACTIVE PROTEIN AS EARLY PREDICTORS OF GESTATIONAL DIABETES

Document Type : Preliminary preprint short reports of original research

Authors

¹ Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

² Department of obstetrics and gynaecology, Faculty of medicine

³ Department of Medical Biochemistry, Faculty of Medicine, Alexandria University

10.21608/alexpo.2021.104803.1308

Abstract

INTRODUCTION:
Diabetes mellitus is a disorder of carbohydrate metabolism which is characterized by impaired ability of the body to produce insulin or to respond to insulin in order to maintain adequate blood glucose level. Diabetes mellitus in pregnancy is a serious health problem associated with both fetal and maternal complications. Diabetes with pregnancy is either gestational diabetes (GDM) or pregestational diabetes. GDM is diagnosed by 75 gram 2-hour OGTT at 24–28 weeks. GDM is diagnosed if the woman has either: a fasting plasma glucose level of 5.6 mmol/litre or above or a 2-hour plasma glucose level of 7.8 mmol/litre or above.
Angiopoietin-like protein 8 (ANGPTL8) is a hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. It is expressed in liver and fat cells. The high sensitivity C reactive protein (hs-CRP) test is a highly sensitive quantification of CRP, which is an acute-phase protein released into the blood by the liver during inflammation.
AIM OF THE WORK:
The aim of the study was to evaluate angiopoietin like protein 8 and high sensitivity C reactive protein as early predictors of gestational diabetes in pregnancy.

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