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Bassiouni, H. (2021). CLINICAL SIGNIFICANCE OF CIRCULATING CIRCADIAN PROTEINS BMAL1 AND PERIOD2 IN PATIENTS WITH HEPATITIS C VIRUS-RELATED LIVER. ALEXMED ePosters, 3(4), 52-53. doi: 10.21608/alexpo.2021.96673.1274
Hadeer Khamis Bassiouni. "CLINICAL SIGNIFICANCE OF CIRCULATING CIRCADIAN PROTEINS BMAL1 AND PERIOD2 IN PATIENTS WITH HEPATITIS C VIRUS-RELATED LIVER". ALEXMED ePosters, 3, 4, 2021, 52-53. doi: 10.21608/alexpo.2021.96673.1274
Bassiouni, H. (2021). 'CLINICAL SIGNIFICANCE OF CIRCULATING CIRCADIAN PROTEINS BMAL1 AND PERIOD2 IN PATIENTS WITH HEPATITIS C VIRUS-RELATED LIVER', ALEXMED ePosters, 3(4), pp. 52-53. doi: 10.21608/alexpo.2021.96673.1274
Bassiouni, H. CLINICAL SIGNIFICANCE OF CIRCULATING CIRCADIAN PROTEINS BMAL1 AND PERIOD2 IN PATIENTS WITH HEPATITIS C VIRUS-RELATED LIVER. ALEXMED ePosters, 2021; 3(4): 52-53. doi: 10.21608/alexpo.2021.96673.1274

CLINICAL SIGNIFICANCE OF CIRCULATING CIRCADIAN PROTEINS BMAL1 AND PERIOD2 IN PATIENTS WITH HEPATITIS C VIRUS-RELATED LIVER

Article 221, Volume 3, Issue 4, December 2021, Page 52-53  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2021.96673.1274
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Author
Hadeer Khamis Bassiouni email
Department of internal medicine faculty of medicine
Abstract
INTRODUCTION
 Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide.
 The circadian clock (CC) is an endogenous timekeeping system that synchronizes 24-hr oscillations of behavioral and biological processes.
 The CC machinery forms a feedback timing circuit and is composed of a series of genes.
 Brain and muscle Arnt-like protein 1 (BMAL1) and Period 2 (PER2) genes are crucial components of the CC.
 Disruption of the circadian rhythms is linked to a variety of diseases including viral infections, liver diseases, metabolic derangements, and cancer.
AIM OF THE WORK
 The present study was conducted to assess the clinical significance of circulating circadian proteins BMAL1 and PER2, positive and negative regulators of the CC, in patients with HCV-related liver disease.
SUBJECTS
 60 patients with chronic HCV infection {20 patients with chronic hepatitis C (CHC), 20 cirrhotic patients without hepatocellular carcinoma (HCC), 20 cirrhotic patients with HCC] and 20 healthy controls.
 Exclusion criteria: other causes of chronic liver disease; infections; inflammatory disorders; or malignancy; cardiac, respiratory or renal disease; previous antiviral or HCC treatment.
Keywords
VIRUS-RELATED; LIVER DISEASE; CIRCULATING CIRCADIAN
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