COMPARISON OF 18F-FDG-PET/CT VERSUS WB DW-MRI IN STAGING AND EVALUATION OF RESPONSE FOR LYMPHOMA PATIENTS

Document Type : Preliminary preprint short reports of original research

Authors

1 Alexandria university

2 Alexandria Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria Egypt.

Abstract

The aim of the study is to assess the diagnostic value of Whole Body DWI in the staging and assessment of treatment response in lymphoma as a viable alternative in comparison to FDG PET/CT. a prospective study enrolled 20 lymphoma patients including aggressive and indolent subtypes D for staging or treatment response assessment. The lesions detected by MRI-DWI were evaluated with PET/CT as the reference standard. The impact of DWI and PET/CT on disease staging was analyzed according to Ann Arbor. The mean age at diagnosis was 58.44 (SD ± 5.16) years. 90% (18/20) had NHL. 6/20 patients were recruited for treatment response. The other 14 patients had 100% agreement in staging; 9were stage IV, 1 stage III, 1 stage II, and 3 were stage I disease. The agreement was moderate (κ = 0.57)for Total nodal sites and very good (κ = 0.84) for extranodal sites. Discordance in extranodal sites in 2 cases included: splenic infiltration at DWI on one and focal Bone Marrow infiltration at FDG PET/CT on the other. Individual sites showed a good agreement κ> 0.69 except for hilar region with a poor agreement (κ = 0.35) but this did not impact staging.DWI is a good alternative to FDG PET/CT and can be used in varied lymphomas and as an alternative for radiation-free imaging due to its good level of agreement to the standard reference. It showed a good evaluation especially of extranodal sites and also nodal sites except for hilar LNs where FDG PET/CT remains superior

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ALEXMED ePosters
Volume 3, Issue 4
December 2021
Pages 26-27

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