Mohamed, M. (2021). ASSESSMENT OF SERUM LEVELS OF INTERLEUKIN-18 AND IMMUNOGLOBULIN E IN PATIENTS WITH CHRONIC SPONATNEOUS URTICARIA AND THEIR RELATION TO SEVERITY OF THE DISEASE. ALEXMED ePosters, 3(4), 25-26. doi: 10.21608/alexpo.2021.91041.1249
Marwa Youssef Mohamed. "ASSESSMENT OF SERUM LEVELS OF INTERLEUKIN-18 AND IMMUNOGLOBULIN E IN PATIENTS WITH CHRONIC SPONATNEOUS URTICARIA AND THEIR RELATION TO SEVERITY OF THE DISEASE". ALEXMED ePosters, 3, 4, 2021, 25-26. doi: 10.21608/alexpo.2021.91041.1249
Mohamed, M. (2021). 'ASSESSMENT OF SERUM LEVELS OF INTERLEUKIN-18 AND IMMUNOGLOBULIN E IN PATIENTS WITH CHRONIC SPONATNEOUS URTICARIA AND THEIR RELATION TO SEVERITY OF THE DISEASE', ALEXMED ePosters, 3(4), pp. 25-26. doi: 10.21608/alexpo.2021.91041.1249
Mohamed, M. ASSESSMENT OF SERUM LEVELS OF INTERLEUKIN-18 AND IMMUNOGLOBULIN E IN PATIENTS WITH CHRONIC SPONATNEOUS URTICARIA AND THEIR RELATION TO SEVERITY OF THE DISEASE. ALEXMED ePosters, 2021; 3(4): 25-26. doi: 10.21608/alexpo.2021.91041.1249
ASSESSMENT OF SERUM LEVELS OF INTERLEUKIN-18 AND IMMUNOGLOBULIN E IN PATIENTS WITH CHRONIC SPONATNEOUS URTICARIA AND THEIR RELATION TO SEVERITY OF THE DISEASE
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University
Abstract
Chronic spontaneous urticaria is defined by recurrent episodes occurring at least twice a week for ≥ 6 weeks without inducible causes. Females are more commonly affected than males. The etiology of CU is heterogeneous. CU has a significant impact on quality of life. CU is a common skin condition that affects up to 5% of the general population. IgE plays an essential role in type I hypersensitivity, which manifests various allergic diseases such as allergic asthma, allergic rhinitis, food allergy, some types of chronic urticaria and atopic dermatitis. IgE-mediated autoimmunity or autoallergy against several autoallergens, including thyroid peroxidase, double stranded DNA, IL-24, thyroglobulin and tissue factor, is thought to play a major role in the pathogenesis of CSU. Interleukin (IL)-18 is a pleotropic cytokine that provides an important link between innate and adaptive immune responses and it can enhance both.It can activate T cells and induce either T-helper (Th) 1 or Th2 responses, depending on the cytokine environment. It has been suggested that IL-18 may play an important role either in autoimmune disorders, characterized by a predominant Th1 response, or in allergic diseases, characterized by a Th2 response.
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