USE OF AUTOLOGOUS ADIPOSE TISSUE DERIVED STEM CELLS FOR TREATMENT OF KNEE OSTEOARTHRITIS: ACLINICAL STUDY

Document Type : Preliminary preprint short reports of original research

Author

Department of Orthopaedic Surgery and Traumatology, Faculty of Medicine, University of Alexandria.

Abstract

Degenerative Osteoarthritis (OA) is considered to be the most prevalent form of arthritis and one of the main causes of disability. It is a condition that affects the joints causing pain, stiffness and difficulty in performing daily activities. The most commonly affected joint is the knee
There is no cure for OA and most treatments aim to manage patients’ symptoms. All these forms of treatments are palliative and only provide pain relief, failing to prevent cartilage damage and further destruction of other joint tissues. Joint replacement is the only currently available treatment able to provide pain relief and satisfactory function recovery, when the final stages of OA are reached.
The regenerative medicine field is developing and showing promising results aiming to stop and revert the degeneration associated with OA. Injection of adipose tissue derived mesenchymal stem cell (MSC) intraarticularly is one of these methods.
AIM OF THE WORK
The aim of this study was to evaluate the efficacy of intra-articular injection of adipose tissue derived mesenchymal stem cells (ADMSC) in the treatment of mild to moderate degenerative knee osteoarthritis.

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