Dermatologic manifestations in patients with polycystic ovary syndrome: their prevalence and assessment in relation to hormonal and metabolic changes

Gaber, Hend Hassan; Abuzeid, Sami Abdelhamid; Abukhedr, Nouran Abdelaziz; Gaafar, Sherif Salah; Bondok, Maha Elsaid

doi:10.21608/alexpo.2020.49095.1070

Dermatologic manifestations in patients with polycystic ovary syndrome: their prevalence and assessment in relation to hormonal and metabolic changes

Document Type : Preliminary preprint short reports of original research

Authors

¹ Alexabdria

² department of dermatology, andrology and venereology, Alexandria university

³ Department of dermatology, andrology and venereology, Alexandria university

⁴ ob/gyn, faculty of medicine, alexandria university

⁵ internal medicine, alexandria university

10.21608/alexpo.2020.49095.1070

Abstract

Polycystic ovary syndrome(PCOS) is considered the most common endocrine disorder affecting females in the reproductive years,and is characterized by being multisystemic with a variety of phenotypes and broad spectrum of manifestations that are strongly influenced by ethnic backgrounds. Cutaneous manifestations represent an important part of the syndrome.The aim of this study was to detect the prevalence of dermatologic manifestations among an Egyptian PCOS cohort and to study the correlation between these manifestations and the underlying hormonal and metabolic changesThe study was conducted on 53 patients diagnosed as PCOS aged 20-40 years and 50 non-PCOS controls of the same age group .In all participants history was taken including family, medical, drug and menstrual history. Anthropometric measurments were recorded and they were subjected to pelvic ultrasonography and to dermatologic examination focusing on hirsutism, acne, androgenetic alopecia and acanthosis nigricans. total Testosterone, free testosterone, DHEAS, prolactin and TSH were measured for the PCOS group. Additionally, the HOMA-IR for insulin resistance was calculated. Among the PCOS patients group prevalence percent of hirsutism 49%, followed by AGA 43.3%, , acne 39.6%and acanthosis nigricans 32% .Having hirsutism in PCOS patients was associated with higher levels of total and free testosterone than being free from hirsutism. the degree of hirsutism (mFGS) showed a weak positive correlation with the serum levels of total and free testosterone. Acne and AGA in PCOS patients seem not to be influenced by serum androgen levels, HOMA-IR nor anthropometric measures..Acanthosis nigricans is more related to the metabolic disorder rather than to hyperandrogenism.

Keywords