Maatouk, S. (2020). STUDY OF THE ASSOCIATION BETWEEN PIWI-interacting RNA 021285 SINGLE NUCLEOTIDE POLYMORPHISM (RS1326306) AND BREAST CANCER IN A COHORT OF EGYPTIAN FEMALE PATIENTS. ALEXMED ePosters, 2(2), 46-46. doi: 10.21608/alexpo.2020.45704.1054
Salma Abdeen Maatouk. "STUDY OF THE ASSOCIATION BETWEEN PIWI-interacting RNA 021285 SINGLE NUCLEOTIDE POLYMORPHISM (RS1326306) AND BREAST CANCER IN A COHORT OF EGYPTIAN FEMALE PATIENTS". ALEXMED ePosters, 2, 2, 2020, 46-46. doi: 10.21608/alexpo.2020.45704.1054
Maatouk, S. (2020). 'STUDY OF THE ASSOCIATION BETWEEN PIWI-interacting RNA 021285 SINGLE NUCLEOTIDE POLYMORPHISM (RS1326306) AND BREAST CANCER IN A COHORT OF EGYPTIAN FEMALE PATIENTS', ALEXMED ePosters, 2(2), pp. 46-46. doi: 10.21608/alexpo.2020.45704.1054
Maatouk, S. STUDY OF THE ASSOCIATION BETWEEN PIWI-interacting RNA 021285 SINGLE NUCLEOTIDE POLYMORPHISM (RS1326306) AND BREAST CANCER IN A COHORT OF EGYPTIAN FEMALE PATIENTS. ALEXMED ePosters, 2020; 2(2): 46-46. doi: 10.21608/alexpo.2020.45704.1054
STUDY OF THE ASSOCIATION BETWEEN PIWI-interacting RNA 021285 SINGLE NUCLEOTIDE POLYMORPHISM (RS1326306) AND BREAST CANCER IN A COHORT OF EGYPTIAN FEMALE PATIENTS
Clinical and chemical pathology, Alexandria Faculty of Medicine, Alexandria University, Alexandria, Egypt
Abstract
Breast cancer (BC) is the most common cancer among women and the most common cause of women`s death from cancer both worldwide and in Egypt. It is a complex disease that results from interaction between genetic susceptibility and environmental risk factors. Approximately 5-10% of all breast cancer cases are caused by genetic mutations, the majority of which can be accounted for (BRCA1) and (BRCA2) but other genes are also involved. PIWI-interacting RNAs (piRNAs) is a class of small non-coding RNAs. Normally piRNAs are involved in the silencing of genetic elements, including transposable elements (TEs). They also play a role in regulation of gene expression. The disruption of piRNAs that normally suppress TE activity may facilitate genomic instability, thereby contributing to tumorigenesis. Aberrant expression of a number of piRNAs has been identified in many cancers. The Pi-RNA 021285 SNP (rs1326306) is a polymorphism in which a guanine nucleotide (G) is substituted with a thymidine (T) nucleotide at base 12 of piR-021285 which results in increased expression of ARHGAP11A gene. ARHGAP11A gene is a protein coding gene located on the long arm of chromosome 15, it is an oncogene that regulates proliferation, invasion and metastases of tumor cells. It is overexpressed in a variety of tumors as colon cancer, brain, lung cancers and breast cancer.
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