Home Articles List Article Information
ALEXMED ePosters
Journal Archive
Volume Volume 7 (2025)
Volume Volume 6 (2024)
Volume Volume 5 (2023)
Volume Volume 4 (2022)
Volume Volume 3 (2021)
Volume Volume 2 (2020)
Volume Volume 1 (2019)
mohamed, S. (2020). STUDY OF SERUM PROGRANULIN LEVEL AND ITS RELATION TO MICROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 1 DIABETES. ALEXMED ePosters, 2(2), 39-39. doi: 10.21608/alexpo.2020.45050.1046
Shaimaa Shaaban mohamed. "STUDY OF SERUM PROGRANULIN LEVEL AND ITS RELATION TO MICROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 1 DIABETES". ALEXMED ePosters, 2, 2, 2020, 39-39. doi: 10.21608/alexpo.2020.45050.1046
mohamed, S. (2020). 'STUDY OF SERUM PROGRANULIN LEVEL AND ITS RELATION TO MICROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 1 DIABETES', ALEXMED ePosters, 2(2), pp. 39-39. doi: 10.21608/alexpo.2020.45050.1046
mohamed, S. STUDY OF SERUM PROGRANULIN LEVEL AND ITS RELATION TO MICROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 1 DIABETES. ALEXMED ePosters, 2020; 2(2): 39-39. doi: 10.21608/alexpo.2020.45050.1046

STUDY OF SERUM PROGRANULIN LEVEL AND ITS RELATION TO MICROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 1 DIABETES

Article 5, Volume 2, Issue 2, October 2020, Page 39-39  XML
Document Type: Preliminary preprint short reports of original research
DOI: 10.21608/alexpo.2020.45050.1046
View on SCiNiTO View on SCiNiTO
Author
Shaimaa Shaaban mohamed email
Department of Internal Medicine, Alexandria University, Alexandria, Egypt
Abstract
Progranulin (PGRN) is a cysteine rich secreted protein, expressed in epithelial cells, immune cells, neurons, and adipocytes. Full length PGRN stimulates cell growth and survival and has anti-inflammatory activity. However, proteolytic cleavage of PGRN producesgranulin peptides (GRNs), some of which stimulate inflammation. Recent studies have demonstrated that activation of inflammatory process may lead to development of diabetic microangiopathy.
Aim of the work
The aim of the present study was to study the relation between serum Progranulin level and microvascular complications in subjects with type 1 diabetes mellitus.
Subjects and methods
This study included 80 subjects classified as: 20 healthy subjects as a control group, 20 diabetic patients with duration of DM less than one year and 40 diabetic patients with duration more than 5 years. Serum progranulin level was measured by ELISA technique. This study included 80 subjects classified as: 20 healthy subjects as a control group, 20 diabetic patients with duration of DM less than one year and 40 diabetic patients with duration more than 5 years. Serum progranulin level was measured by ELISA technique.
Keywords
Progranulin (PGRN); Neuropathy; Nephropathy
Statistics
Article View: 260