STUDY OF THE EFFECT OF ACTIVE INFECTIONS ON DIHYDRORHODAMINE (DHR) TEST IN CHRONIC GRANULOMATOUS DISEASE PATIENTS (CGD)
shady
kamal
Clinical pathology, Faculty of medicine, Alexandria university, Alexandria, Egypt
author
text
article
2020
eng
Chronic granulomatous disease (CGD) is the most common type of primary innate immune deficiency caused by defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase enzyme in the neutrophils. (1) It’s considered as a fatal granulomatous disease of childhood as most patients with CGD die by 10 years of age. (2) Any mutation at one of the genes encoding for glycoproteins that are forming the five subunits of the NADPH oxidase enzyme leads to CGD. If the mutation leaves some residual NADPH oxidase activity intact the clinical expression of the disease is attenuated and prognosis is better. (3) CGD can be treated by conventional treatment, stem cell transplantation or genetic therapy. (4) The (DHR) test was approved to be the gold standard for diagnosis of CGD. (5) Aim of the work The aim of the present study is to detect the effect of active infections on the interpretation of DHR test results in chronic granulomatous disease patients and patients with active infections with no evidence of CGD.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
1
2
https://alexpos.journals.ekb.eg/article_107732_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.38715.1003
NUTRITIONAL STATUS AND ITS DETERMINANTS OF CHILDREN WITH ACUTE LYMOPHOCYTIC LEUKEMIA ATTENDING THE OUTPATIENT CLINIC, SMOUHA ALEXANDRIA UNIVERSITY CHILDREN'S HOSPITAL
sara
abd elaziz
Department of Community Medicine
author
text
article
2020
eng
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, representing 75%–80% of acute leukemias among children. ALL children are at increased risk for malnutrition mostly due to the treatment related adverse events. This fact is often ignored during their management. Malnutrition may vacillate between weight loss and excessive weight gain. The goal of nutritional assessment in children with cancer is to assess the nutritional needs, to provide the optimal nutrition, to prevent or treat nutritional disorders and the increased morbidity and mortality that accompany them. Nutrition is a supportive care modality that can improve tolerance to chemotherapy, survival, increased quality of life, and decreased risk of infection in children undergoing anticancer therapy.Aim of the work Assessment of nutritional status of children with ALL attending the Pediatric Hematology Oncology Unit (PHOU), Smouha Hospital for Pediatric Medicine and Surgery, to give a basis for providing patients with nutritional intervention .
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
3
4
https://alexpos.journals.ekb.eg/article_107605_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.38431.1002
CLINICAL, DEMOGRAPHIC AND LABORATORY RISK FACTORS OF SUICIDE IN A SAMPLE OF MAJOR DEPRESSION DISORDER PATIENTS
Polycarpe
UWIHIRWE
Neuropsychiatry,Faculty of medicine
author
text
article
2020
eng
Depression is defined as a condition affecting negatively the feelings, thinking and the way of acting; manifested by loss of interest, feelings of sadness, decrease in activities once enjoyed before, discouragement or hopelessness. Major depression disorder itself being a big burden worldwide and affecting general population at rate of 17% regardless of age consideration. Worldwide depression affects people at estimated rate of one in 15 adults in any given year and one in six people will experience depression at some time in their life. Diagnosed and treated, Major depression disorder is a curable psychiatric condition.Suicide is defined suicide as act of intentionally causing one’s own death. Suicide is different from parasuicide which is action of self-harming without intention to die. It is the 10th leading cause of death in USA with 44,000 deaths every year and in 2015 about 800,000 suicide deaths reported worldwide. Major depression disorder (MDD) leads to suicide of about 80% in all suicide attempts committed by psychiatric patients.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
5
6
https://alexpos.journals.ekb.eg/article_108042_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.39277.1005
Magnetic resonance imaging parameters of meningioma consistency and correlation with intraoperative findings
Ahmed
Alkassas
Faculty of medicne
author
text
article
2020
eng
Meningioma consistency, firmness or softness as it relates to resectability, affects the difficulty of surgery and, to some degree, the extent of resection. Preoperative knowledge of tumor consistency would affect preoperative planning and instrumentation. Furthermore, preoperative identification of vascularity of meningiomas can potentially reduce intraoperative blood loss and facilitate surgical resection. The study was conducted during the period between January 2018 and October 2019 on a total of 40 patients ranging in age from 40 – 70 years, presenting by imaging findings suggestive of underlying meningioma referred from Neurosurgery department and clinic for further pre-operative MRI consistency and vascularity assessment. Meningiomas were categorized into 3 categories according to intraoperative consistency; a) soft consistency including 19 cases (47.5%), b) intermediate consistency including 14 cases (35%) & c) firm consistency including 7 cases (17.5 %). Compared to visual assessment of T2 signal intensity and quantitative diffusion based ADC values, tumor to cerebellar peduncle T2 intensity (TCTI) ratios showed the most significant MRI parameter in correlation with operative consistency of meningiomas, with soft lesions showing TCTI ranging from 1.75 to 2.87, intermediate consistency lesions ranging from 1.3 to 1.6, and firm lesions ranging from 0.9 to 1.2. ROC analysis showed 100% sensitivity, specificity, PPV and NPPV for TCTI ratio >1.6 in prediction of soft consistency, TCTI ratio ≤1.2 for firm consistency with intermediate consistency lesions having TCTI between >1.2 and ≤1.6.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
7
8
https://alexpos.journals.ekb.eg/article_109095_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.39826.1008
ROLE OF LATERAL PLAIN X-RAY VIEW IN EVALUATION OF ADOLESCENT IDIOPATHIC SCOLIOSIS
Omar
Abdelmegid
Department of Orthopaedic Surgery and Traumatology Faculty of Medicine, Alexandria University, alexandria, egypt
author
Hesham
Elsaghir
Department of Orthopaedic Surgery and Traumatology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
author
Yasser
Allam
Department of Orthopaedic Surgery and Traumatology Faculty of Medicine, Alexandria University, Alexandria, Egypt
author
Adel
Ramadan
Department of Radiology, Faculty of medicine, university of Alexandria, Alexandria , Egypt
author
text
article
2020
eng
Objective: new method of evaluating the thoracic modifier in adolescent idiopathic scoliosis using true lateral digital x-ray views of the fifth thoracic vertebra and the twelfth thoracic vertebra.Methods: prospective study included thirty patients with adolescent idiopathic scoliosis. Lenke classification type I, II, III, IV were included in this study. Every patient was subjected to thorough clinical and radiological examination including Plain x-ray long standing Antero-posterior view. From this view, Coronal tilt angle of T5 and T12 was calculated . According to the CTA of T5 and T12, Two lateral view images were obtained, one focusing on T5 and the other on T12 to measure the degree of sagittal tilt of T5 and T12. Thoracic modifier using the new method is calculated using cobb’s method in which cobb angle is equal to summation of T5 STA and T12 STA. All mentioned angles were measured using Surgimap. Results: T5 STA ranged from -14.70º to 28.80º with a mean of 6.50 ± 10. T12 STA ranged from 3.40º to 41.10º with a mean of 21.40 ± 8.49. Total thoracic modifier ranged from 3.40º to 41.10º with a mean of 21.40 ± 8.49.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
27
27
https://alexpos.journals.ekb.eg/article_116667_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.43424.1039
APPLICATION OF A REHABILITATION PROGRAM OF PRAGMATIC LANGUAGE SKILLS FOR DELAYED LANGUAGE SCHOOL-AGE EGYPTIAN CHILDREN.
Walaa
el-sayed
phoniatrics, faculty of medicine ,Alexandria university, Alexandria ,Egypt
author
riham
Aly El-Maghraby
phoniatrics, faculty of medicine, Alexandria university, Alexandria, Egypt
author
text
article
2020
eng
The study of actual language use is called “pragmatics”. The literal meaning of an utterance is necessary, but not sufficient for the partner to reconstruct the meaning conveyed by the actor. Pragmatic competence requires the use of both linguistic and extra-linguistic communication in context, such as the ability to attribute mental states to others. Children with Pragmatic impairments may contribute less information or offer information that is either irrelevant or unintelligible leading to difficulties for the listener in understanding the gist of the conversation, so it has negative impact on the social and peer relationships. The Interventions of pragmatic impairments depend mainly on improving the four important aspects for any effective social communication contexts which are social interactions, social cognition, language processing and pragmatic skills. The aim of the work was to apply the modified “Say and Do positive pragmatic fun sheets”, a rehabilitation program for pragmatic skills and detect its effectiveness in rehabilitation of pragmatic impairments in Egyptian school-age children. The results was A statistically highly significant increase in the scores of the cases of the school age studied groups A and B was seen when comparing between pre and post therapy, and no statistically significant difference when comparing post therapy scores between the two studied groups. The conclusion was that the Arabic version of “Say and Do positive pragmatic fun sheets” program is an effective rehabilitation tool for children with pragmatic impairments.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
2
3
https://alexpos.journals.ekb.eg/article_107731_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.38244.1000
STUDY OF CLINICO-PATHOLOGICAL CHANGES BEFORE AND AFTER CORTICOSTEROID THERAPY IN CASES OF IDIOPATHIC GRAULOMATOUS MASTITIS
Ahmed
Mansy
Surgery Department, Faculty of Medicine, Alexandria University, Alexandria,Egypt
author
text
article
2020
eng
Granulomatous disease of the breast is a rare differential diagnosis with an estimated incidence of 2.4 per 100,000 women and 0.37% in the US. Idiopathic Granulomatous Mastitis (IGM) is a non-infectious inflammation that was first described in 1972 by Kessler and Wolloch. It is an infrequently reported chronic disease of the breast of unclear etiology. Although its etiology has not been explained definitively, various factors including autoimmunity are probably involved. It has been suggested that breast feeding and use of oral contraceptives may have a role in IGM. It has various spectrum of presentations including single or multiple painful or painless breast swelling(s), breast ulcers, and sinus or abscess formation. Definitive diagnosis is through histopathological evaluation of the breast tissues achieved by core needle biopsy (CNB) showing noncaseating granulomas with chronic inflammatory cells such as histiocytes and multinucleated giant cells. This study was performed to evaluate the outcome of nonsurgical treatment of IGM with oral corticosteroids in correlation with pathological changes before and after treatment.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
6
7
https://alexpos.journals.ekb.eg/article_108980_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.39281.1006
STUDY OF SERUM S100P LEVEL AND ITS RELATION TO DIABETIC PERIPHERAL NEUROPATHY IN PATIENTS WITH TYPE 2 DIABETES
Aya
Allam
department of internal medicine, faculty of medicine , Alexandria university, Egypt
author
text
article
2020
eng
Diabetic peripheral neuropathy (DPN) is the most common chronic complication of diabetes. DPN is the commonest cause of neuropathy worldwide accounting for about 75% of the diabetic neuropathies. The most critical complications of DPN include foot ulcers, Charcot foot abnormalities, injuries, and eventually, lower-extremity amputation, especially when concomitant peripheral vascular disease causes foot ischemia. S100P, a 95 amino acid protein, functions as intracellular regulator of diverse cellular processes including protein phosphorylation, cytoskeletal function, and protection from oxidative cell damage. S100P can act in an autocrine manner through binding to receptor for advanced glycation end products (RAGE). RAGE is the main receptor through which AGE signalling, one of the main pathophysiological mechanisms of diabetes and DPN, is mediated. This activation of RAGE by the S100P may be a source of underlying neuropathy in diabetes through their contribution to oxidative stress, activation of caspase-3 and changes induced in the DNA molecules. So, distorted expression of the S100P may be implicated in the pathogenesis of DPN through activation of the advanced glycation end products-RAGE alliance.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
9
10
https://alexpos.journals.ekb.eg/article_109734_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.40413.1012
STUDY OF NR1I2 GENE POLYMORPHISM (A7635G) AND STEROID RESISTANCE IN EGYPTIAN CHILDREN WITH IDIOPATHIC NEPHROTIC SYNDROME
Rofaida
Rakha
clinical pathology, faculty of medicine, Alexandria
author
text
article
2020
eng
Nephrotic Syndrome (NS) is a common chronic disorder, characterized by alterations of the permeability of the glomerular capillary wall, resulting in its inability to restrict the urinary loss of protein. INS ( also called nephrosis ) is defined by the combination of a nephrotic syndrome (proteinuria, hypoalbuminemia, hyperlipidemia, and edema) and non-specific histological abnormalities of the kidney including minimal changes (MC), focal and segmental glomerular sclerosis (FSGS), and diffuse mesangial proliferation. As INS response to treatment with steroids varies. Several studies was done to analyze the correlation between steroid -related genes and the response to steroid treatment.The influence of polymorphisms on treatment response of children with INS was investigated. The results may be useful for predicting the treatment response of children with INS.. Nowadays it is clear that NR1I2 gene is also involved in regulation of intermediate metabolism through trans-activation and trans-repression of genes controlling glucose, lipid, cholesterol, bile acid, and bilirubin homeostasis. so it affects steroid drug metabolism and as a consequence the mutation of this gene may affect the response of NS children to treatment. valuable information in prognosis and pathology of the disease types.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
4
5
https://alexpos.journals.ekb.eg/article_107735_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.38658.1004
ASSESSMENT OF PATTERN, SEVERITY AND OUTCOME OF ACUTE PESTICIDE POISONING AMONG PATIENTS ADMITTED TO ALEXANDRIA POISON CENTER
Athar
Mohammed
Forensic medicine and clinical toxicology, faculty of medicine, Alexandria University, Alexandria, Egypt
author
text
article
2020
eng
Pesticides are broadly used in agricultural and environmental sectors as well as public health perspectives. According to the Food and Agriculture Organization of the United Nations (FAO), pesticide is defined as any substance or mixture of substances intended for preventing, destroying or controlling any pest, unwanted species of plants or animals causing harm or interfering with the production , processing, storage, transport or marketing of food, agricultural commodities, wood and wood products or animal feedstuffs or substances which may be administered to animals for control of insects, arachnids or other pests in or on their bodies.In Egypt and developing countries, there is an insufficient pesticides regulation, lack of surveillance systems, less enforcement, lack of training, and easy access to a wide variety of pesticides. Therefore the health-related issues associated with the exposure to pesticides are increasing.Pesticide poisoning accounts for significant morbidity and mortality worldwide. The UN estimates an average of about 200,000 people die from the toxic exposure of pesticides per year across the world.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
10
11
https://alexpos.journals.ekb.eg/article_109969_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.40120.1010
EVALUATION OF METHYLATION STATUS OF PROGESTERONE RECEPTOR GENE IN CASES WITH ENDOMETRIOSIS
Mohamed
Amer
Alexandria university. Obstetric&gynecology
author
text
article
2020
eng
Endometriosis represents a common gynecological disease which affects >10% of women of reproductive age. Endometriosis is the presence and growth of functional endometrial tissue, outside the uterine cavity, primarily in the ovaries, pelvic peritoneum and rectovaginal septum. The main pathological processes are peritoneal inflammation and fibrosis, and the formation of adhesions and ovarian cysts. Infertility and pelvic pain are the predominant symptoms. Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. Epigenetic mechanisms may play a significant role in the origin and progression of endometriosis. Epigenetics encompasses several different phenomena, such as DNA methylation, histone modifications, RNA interference and genomic imprinting. Progesterone induces the differentiation of endometrial stromal cells to decidualized cells and glandular epithelial cells to the secretory phenotype. Representative molecular markers of progesterone action include increased production of epithelial glycodelin and stromal prolactin in the endometrium. Progesterone resistance has been viewed as a general feature in endometriosis and can be attributed to the extremely low progesterone-receptor levels in endometriotic tissue.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
11
12
https://alexpos.journals.ekb.eg/article_110854_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.40950.1016
ROLE OF MAGNETIC RESONANCE IMAGING SIALOGRAPHY IN DIAGNOSIS OF SALIVARY GLAND DUCT DISEASES
Hesham
Zoheir
Department of Radiodiagnosis, Faculty of medicine, Alexandria University, Alexandria, Egypt
author
text
article
2020
eng
Salivary gland duct diseases have been commonly addressed and investigated using ultrasound and conventional radiographic techniques. However, ultrasound assessment displays a limited view of the salivary ductal tree. While conventional X-ray or CT sialography may provide acceptable spatial anatomy, a number of drawbacks were reported, with complications such as trauma or acinar rupture and sepsis, and contraindications such as acute parotitis or contrast material allergy, not to mention the required high operator experience and patient compliance.MR sialography is a new nonionizing noninvasive technique that is being developed to evaluate diseases of the salivary ducts. Adequate assessment of the duct system is obtainable, with no involvement of invasive techniques, or contrast material or radiation exposure.MR sialography offers many advantages over alternative imaging techniques such as conventional x-ray sialography. These include the noninvasive technique; avoiding contrast media, ionizing radiation, and dependence on an experienced operator.Details provided by MRI sialography are considered to be of value for the interventional decision-making process. These details include the distance of the obstructing cause from the ductal punctum, the size and number of stones, ductal mapping and diameters, Upstream dilatation, and ductal condition.
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
11
12
https://alexpos.journals.ekb.eg/article_111245_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.41498.1020
ASSESSMENT OF THE EFFECT OF PREGESTATIONAL DIABETES AND RISK OF ADVERSE MATERNAL, PERINATAL AND NEONATAL OUTCOMES IN EGYPT
Amira
Mahmoud
Obstetrics and Gynecology, Faculty of Medicine, Alexandria University
author
Abdelmoneim
Fawzy
Department of Obstetrics and Gynaecology , Faculty of Medicine, University of Alexandria, Egypt
author
Rehab
Noureidin
Department of Obstetrics and Gynaecology , Faculty of Medicine, University of Alexandria, Egypt
author
Mohammed
Farag
Department of Obstetrics and Gynaecology , Faculty of Medicine, University of Alexandria, Egypt
author
text
article
2020
eng
Diabetes mellitus is one of the most common pre-existing maternal disorders and complicated approximately 1.3% of all pregnancies Most women with pre-gestational diabetes (PGD) characterized by disturbance in glucose metabolism may be due to variable degrees of insulin resistance (type 2), or a consequence of autoimmune destruction of the pancreatic β-cells (type 1). Furthermore, PGD has also been associated with increased risk of maternal complications including shoulder dystocia, gestational hypertension, and pre-eclampsia , making pre- pregnancy care particularly glycaemic control and obstetrical interventions of great importance. The aim of this work was to assess the effect of pre-gestational diabetes and risk of adverse maternal, prenatal & neonatal outcomes in Alexandria-Egypt. From the results of this study we concluded that The patients with elevated HbA1C value of the increased risk of congenital fetal malformation and preeclampsia when the cut off value is > 6.9 , And risk of natal complications and respiratory distress when the cut off value is > 6.8 And affect time of delivery and abortion when the cut off value is > 7.0 . Diabetes plays an increasing role in the number of children born with congenital anomalies
ALEXMED ePosters
Alexandria University, Faculty of Medicine
2682-2636
2
v.
1
no.
2020
12
13
https://alexpos.journals.ekb.eg/article_111303_d41d8cd98f00b204e9800998ecf8427e.pdf
dx.doi.org/10.21608/alexpo.2020.41947.1025